PHOSPHO-C-ABL (TYR245) PAB 10 BLOT BIOSOURCE (TM)

Background/Target Information

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR. and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

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Bioinformatics

Gene Aliases:

p150, RP11-83J21.1, ABL, c-ABL, v-abl, JTK7, bcr/abl

Protein Aliases:

Abelson tyrosine-protein kinase 1, bcr/c-abl oncogene protein, c-abl oncogene 1, receptor tyrosine kinase, proto-oncogene c-Abl, proto-oncogene tyrosine-protein kinase ABL1, tyrosine-protein kinase ABL1, v-abl Abelson murine leukemia viral oncogene homolog 1, p150, c-ABL, Abelson murine leukemia viral oncogene homolog 1, Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine kinase ARG

Entrez Gene ID:

(Human) 25

UniProt ID:

(Human) P00519

Biological Process -

 Protein metabolism and modification  Protein modification  Protein phosphorylation  Signal transduction  Intracellular signaling cascade  Immunity and defense  Stress response  Oncogenesis  Oncogene  Developmental processes  Cell cycle  Cell cycle control  Apoptosis  Induction of apoptosis  Cell structure and motility  Cell motility

Molecular Function -

 Kinase  Protein kinase  Non-receptor tyrosine protein kinase