Apolipoprotein E (apoE) is a 34 kD heparin binding glycoprotein involved in lipid transport and lipoprotein metabolism. It is present in plasma lipoprotein particles such as chylomicrons, VLDL and HDL. ApoE is also present in large amounts at sites of neurological damage and appears to be involved in recycling of apoptotic remnants and of amyloidal aggregates. ApoE is mainly produced in the liver and by macrophages, but also by other cell types such as smooth muscle cells or neuronal cells. ApoE exists in three isoforms, apoE2, apoE3 and apoE4. Of these, apoE4 is associated with Alzheimer’s disease. Normal concentration of apoE in plasma is approximately 30-40 µg/ml.
Mouse monoclonal antibody to human and monkey apolipoprotein E, clone E981. Suitable as capture antibody in ELISA in combination with detection mAb E887; biotinylated (product code 3712-6)
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