Apolipoprotein E (apoE) is a 34 kD heparin binding glycoprotein involved in lipid transport and lipoprotein metabolism. It is present in plasma lipoprotein particles such as chylomicrons, VLDL and HDL. ApoE is also present in large amounts at sites of neurological damage and appears to be involved in recycling of apoptotic remnants and of amyloidal aggregates. ApoE is mainly produced in the liver and by macrophages, but also by other cell types such as smooth muscle cells or neuronal cells. ApoE exists in three isoforms, apoE2, apoE3 and apoE4. Of these, apoE4 is associated with Alzheimer’s disease. Normal concentration of apoE in plasma is approximately 30-40 µg/ml.
Mouse monoclonal antibody to human apolipoprotein E, clone E887. Suitable as detection antibody in ELISA and ELISpot in combination with mAb E276 (product code 3712-3) for human apo E or mAb E981 (product code 3712M-3) for monkey apo E.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
