1717-0909 recognizes the 60 kDa mammalian Calcineurin catalytic subunit.
Calcineurin is a calmodulin binding protein found in the brain that exists as heterodimer composed of a calmodulin-binding, catalytic alpha-subunit and a calcium-binding beta-subunit. It plays a role in the immune response by activating the the transcription of interleukin 2 and is a target for immunosuppressive drugs such as cyclosporin.
Species Cross-Reactivity
Target Species
Cross Reactivity
Mammals
Expected from Sequence
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
Immunohistology - Frozen
1/250 - 1/1000
Western Blotting
1/250 - 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
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