Description: Interleukin 16 (IL-16), also called LCF, is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. The native IL-16 is a proteolytic cleavage product of the pro-IL-16 generated by proteases present in or on activated CD8+ cells. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and mouse IL-16 have significant cross reactivity.
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