Description: The polyclonal antibody reacts with human, mouse, and rat FLIP (N-terminus); the antibody was raised against amino acid 2-18 of human FLIP and recognizes all FLIP variants of human, mouse and rat origin. Cellular FLIP, FLICE-like inhibitory proteins, exist as a long c-FLIPL and a short c-FLIPS splice variant, both of them capable of protecting cells from death receptor-mediated apoptosis. FLIP proteins structurally resemble caspase-8 except that they lack proteolytic activity. FLIP variants are highly expressed in tumor cells, T lymphocytes and healthy, but not injured, myocytes; this suggests a critical role of FLIP as endogenous modulators of apoptosis. FLIP are recruited to the death-inducing signaling complex and interfere with the recruitment of caspase-8.
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