Description: The RMT1-10 monoclonal antibody reacts with mouse TIM-1, a member of newly identified T cell immunoglobulin domain, mucin-like domain (TIM) gene family. RMT1-10 reacts with TIM-1 from C57Bl/6 mouse. RMT1-4, another antibody specific for TIM-1, reacts with the TIM-1 protein from both BALB/c and C57Bl/6 strains. TIM family of proteins are transmembrane proteins expressed by CD4 T cells. Recent studies demonstrate that the TIM family, particularly TIM-1, plays a critical role in immune responses that regulate the development of atopic diseases. Human TIM-1 is a functional receptor for hepatitis A virus (HAV). In humans, certain polymorphic variants of TIM-1 are strongly associated with protection against atopy, and this association occurs only in individuals who have had past infection with hepatitis A virus (HAV). Activation of T cells through TIM-1 by HAV or by its natural ligand may affect T cell differentiation and the development of Th2-driven allergic inflammatory responses.
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