Description: The monoclonal antibody Ham151-149 recognizes mouse Bim, a pro-apoptotic protein belonging to the Bcl-2 family. Bim initiates apoptosis through interactions with other Bcl-2 proteins via the BH3 domain. Transgenic animals suggest a role for Bim in regulating negative selection in the thymus. Additionally, Bim and IL-7 levels are critical for the survival and development of B lymphocytes; Bim expression is upregulated during development. This is consistent with studies of mice lacking Bim, which show an increase in the number of mature B and myeloid cells. Expression of Bim is widespread; hematopoietic, epithelial, germ line and neuronal cells express this protein. Several splice variants have been identified and shown to have varying levels of functionality. Finally, Bim can be phosphorylated resulting in increased apoptotic activities.
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