Clone HTA125 reacts with CD284, a type I transmembrane signaling receptor, also known as Toll-like receptor 4 (TLR4). Toll-like receptors are a family of pattern recognition receptors detecting the presence and characteristics of an infection and induce appropriately tailored innate and adaptive immune responses. TLR4 associates with its co-receptor MD-2. Together with LBP and CD14 this complex is responsible for recognition and signaling upon specific lipopolysaccharide (LPS) recognition. TLR4 is expressed on monocytes, myeloid dendritic cells, and low levels on B cells and granulocytes in human peripheral blood. HTA125 is able to block LPS induced signaling and recognizes predominantly human TLR4 associated with MD-2. ¹-⁶
原厂资料：
Clone HTA125 reacts with CD284, a type I transmembrane signaling receptor, also known as Toll-like receptor 4 (TLR4). Toll-like receptors are a family of pattern recognition receptors detecting the presence and characteristics of an infection and induce appropriately tailored innate and adaptive immune responses. TLR4 associates with its co-receptor MD-2. Together with LBP and CD14 this complex is responsible for recognition and signaling upon specific lipopolysaccharide (LPS) recognition. TLR4 is expressed on monocytes, myeloid dendritic cells, and low levels on B cells and granulocytes in human peripheral blood. HTA125 is able to block LPS induced signaling and recognizes predominantly human TLR4 associated with MD-2. ¹-⁶
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